New Orleans Saints quarterback Drew Brees used a Twitter post to express support for the city after Isaac lashed the area with high wind and flooding rain.
In a post Thursday afternoon, Brees said: "We are about to take the field in Tennessee, but our hearts are with New Orleans and its residents. May God watch over us all."
The Saints were scheduled to play the Tennessee Titans in a preseason game Thursday.
Brees has been involved in recovery in New Orleans and his "Rebuilding Dreams" campaign raised more than $2 million for playgrounds, athletic fields and schools.